Scholar Project Database

Tacrolimus Induces Fibroblast to Myofibroblast Transformation via a TGF-β-Dependent Mechanism to Contribute to Renal Fibrosis

Project Location/Site: Wright State University Boonshoft School of Medicine
Key Outcomes:
Findings demonstrate that tacrolimus-induced loss of calcineurin activity is accompanied with enhanced TGF-β receptor activation and signaling. Notably, increasing concentrations of anti-TGF-β neutralizing antibodies failed to abolish aberrant TGF-β signaling nor increased espression of profibrotic markers.